nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-183-11-51-61nogr-1476Research ArticleКЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯCLINICAL GASTROENTEROLOGYНеалкогольная жировая болезнь печени и метаболический синдром в детском возрастеNon-alcoholic fatty liver disease and metabolic syndrome in childhoodВласовН. Н.VlasovN. N.

Власов Николай Николаевич, к. м. н., доцент кафедры детских болезней.

194100, Санкт-Петербург, ул. Литовская 2

Nikolai N. Vlasov, Candidate of Medical Sciences, Associate Professor of the Department of Children’s Diseases

194100 St. Petersburg, st. Litovskaj 2

Vlassovnik12@yahoo.comКорниенкоЕ. А.KornienkoE. A.

Корниенко Елена Александровна, д. м. н., профессор кафедры детских болезней.

194100, Санкт-Петербург, ул. Литовская 2

Elena A. Kornienko, Doctor of Medical Sciences, Professor of the Department of Children’s Diseases

194100 St. Petersburg, st. Litovskaj 2

ФБГОУ ВО Санкт-Петербургский государственный педиатрический медицинский университет МЗ РФРоссияSt. Petersburg State Pediatric Medical University, Ministry of Health of the Russian FederationRussian Federation202013112020183115161Copyright © Власов Н.Н., Корниенко Е.А., 20202020Власов Н.Н., Корниенко Е.А.Vlasov N.N., Kornienko E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/1476

Имеются многочисленные факты, что в основе развития неалкогольной жировой болезни печени (НАЖБП) лежит инсулин резистентность, гиперинсулинемия и ожирение. Болезнь теперь рассматривают как печеночный компонент метаболического синдрома (МС).

64 ребёнка с НАЖБП были оценены на стигмы метаболического синдрома. Также был сделан анализ о состоянии проблемы по данным литературы относительно общих звеньев патогенеза этих состояний, методов диагностики и лечения НАЖБП.

Все составляющие МС с разной частотой наблюдаются у больных с НАЖБ. Это заболевание вместе с сахарным диабетом 2 типа становится очень распространенными заболеваниями и в детском возрасте. Заболеваемость НАЖБП у детей постоянно растет, она стала встречаться у младенцев, возможен исход в цирроз печени в пределах детского возраста, хотя прогноз при НАЖБП остается точно неопределенным. Снижение веса при назначении диеты с низким гликемическим индексом, регулярные физических упражнения и другие изменения образа жизни являются основой лечения НАЖБП, но пока не слишком эффективным по разным причинам. В этих условиях необходимо повысить роль первичной профилактики МС и НАЖБП.

There is ample evidence that insulin resistance, hyperinsulinemia, and obesity are at the heart of the development of non-alcoholic fatty liver disease (NAFLD). The disease is now considered as the hepatic component of metabolic syndrome (MS).

64 children with NAFLD were assessed for metabolic syndrome stigma. An analysis was also made on the state of the problem according to the literature on the general links of the pathogenesis of these conditions, methods of diagnosis and treatment of NAFLD.

All components of MS are observed with different frequencies in patients with NAFD. This disease, together with type 2 diabetes mellitus, becomes very common diseases in childhood. The incidence of NAFLD in children is constantly growing, it has begun to occur in infants, an outcome in cirrhosis of the liver is possible within childhood, although the prognosis for NAFLD remains definitely uncertain. Weight loss with a low glycemic index diet, regular exercise, and other lifestyle changes are the mainstay of NAFLD treatment, but not yet very effective for various reasons. In these conditions, it is necessary to increase the role of primary prevention of MS and NAFLD.

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The authors declare that there are no conflicts of interest present.