nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-183-11-11-19nogr-1467Research ArticleПЕРЕДОВАЯ СТАТЬЯLEADING ARTICLEМикробиота кишечника и метаболический синдромGut microbiota and metabolic syndromehttps://orcid.org/0000-0002-1095-8787ГриневичВ. Б.GrinevichV. B.

Гриневич Владимир Борисович, заведующий 2 кафедрой (терапии усовершенствования врачей), д. м. н., профессор

194044, Санкт-Петербург, улица Академика Лебедева, д. 6

Vladimir B. Grinevich, Head of 2nd Therapy department of postgraduate education, DSci, professor; Scopus Author ID: 7005167197

194044, St. Petersburg, Akademika Lebedev street, 6

РадченкоВ. Г.RadchenkoV. G.

Радченко Валерий Григорьевич, д. м. н., профессор 2 кафедры (терапии усовершенствования врачей)

194044, Санкт-Петербург, улица Академика Лебедева, д. 6

Valery G. Radchenko, M.D., D. Sc. (Medicine), Professor of 2nd Therapy department of postgraduate education

194044, St. Petersburg, Akademika Lebedev street, 6

radchenkovaler@mail.ruФГБВОУ ВО «Военно-медицинская академия имени С. М. Кирова» МО РФРоссияMilitary Medical Academy named after S. M. KirovRussian Federation202013112020183111119Copyright © Гриневич В.Б., Радченко В.Г., 20202020Гриневич В.Б., Радченко В.Г.Grinevich V.B., Radchenko V.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/1467

Метаболический синдром связан с актуальными заболеваниями, такими как ожирение, сахарный диабет, артериальная гипертензия, которые сопровождаются изменениями микробиоты кишечника и функционирования иммунной и нейро-гуморальных систем организма. Не умаляя роли факторов наследственности и окружающей среды, кишечная микробиота вносит существенный вклад в развитие метаболических нарушений и ожирения, модулируя каскадные ферментативные реакции макроорганизма, взаимодействуя с рецепторами непосредственно и/или при помощи собственных метаболитов и сигнальных молекул.

Целью работы явился анализ литературных данных, полученных при изучении роли микробиоты кишечника в развитии метаболического синдрома (МС).

Результаты. Представлен обзор современной литературы о роли кишечной микробиоты в развитии метаболического синдрома. Обсуждаются особенности мукозной микрофлоры толстой кишки, роль бактериальных пленок, эпителиальной выстелки слизистой кишки в формировании микробно-тканевого комплекса кишечника, как ведущих звеньев метаболических нарушений. В статье представлены данные знчимости короткоцепочных жирных кислот, бактериального генома в развитии ожирения и сахарного диабета 2-го типа.

Metabolic syndrome is associated with current diseases, such as obesity, diabetes, hypertension, which are accompanied by changes in the intestinal microbiota and the functioning of the immune and neuro-humoral systems of the body. Without detracting from the role of heredity and environmental factors, the intestinal microbiota makes a significant contribution to the development of metabolic disorders and obesity by modulating cascading enzymatic reactions of the macroorganism, interacting with receptors directly and/or using its own metabolites and signaling molecules.

The purpose of study was to analyze the literature data obtained in the study of the role of the intestinal microbiota in the development of metabolic syndrome (MS).

Results: A review of current literature on the role of intestinal microbiota in the development of metabolic syndrome is presented. The features of the mucosal microflora of the colon, the role of bacterial films, epithelial lining of the intestinal mucosa in the formation of the intestinal microbial-tissue complex as the leading links of metabolic disorders are discussed. The article presents data on the variability of short-chain fatty acids, bacterial genome in the development of obesity and type 2 diabetes.

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The authors declare that there are no conflicts of interest present.