nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-179-7-152-157nogr-1409Research ArticleОБЗОРREVIEWСиндром низкой резистентности к гистамину: причина или следствие патологии ЖКТ?Low histamine resistance syndrome: is it cause or result of gastrointestinal tract pathology?https://orcid.org/0000-0002-8501-748XТурчинаМ. С.TurchinaM. S.

Турчина Мария Сергеевна - доцент кафедры внутренних болезней.Орел.

Mariya S. Turchina - Associate Professor, Department of Internal Medicine.Orel.

turchina-57@mail.ruhttps://orcid.org/0000-0002-7224-3277КарасеваЗ. В.KarasevaZ. V.

Карасева Зоя Владимировна - студентка 6 курса.Орел.

Zoya V. Karaseva - 6 year student.Orel.

Орловский государственный университет имени И.С. ТургеневаРоссияOrel State UniversityRussian Federation20202709202007152157Copyright © Турчина М.С., Карасева З.В., 20202020Турчина М.С., Карасева З.В.Turchina M.S., Karaseva Z.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/1409

В настоящее время в РФ, как и во всем мире, отмечается рост аллергических заболеваний, в том числе растет количество гастроинтестинальных проявлений аллергии. При этом наряду с Ig-E-опосредованными реакциями имеют место анафилактоидные реакции, обусловленные избыточным высвобождением гистамина и других биологически активных веществ из тучных клеток. Данные патологические процессы могут способствовать обострению функциональных расстройств желудочно-кишечного тракта, усиливая субклиническое воспаление слизистой оболочки, способствуя развитию висцеральной гиперчувствительности и нарушениям моторики ЖКТ. В то же время, большинство практикующих врачей не уделяет должного внимания возможному влиянию аллергических и псевдоалларгических реакций на течение синдрома раздраженной толстой кишки и функциональной диспепсии. При этом, необходимо учесть, что в случае синдрома низкой резистентности к гистамину у большинства пациентов достаточно введения ограничений в рацион питания и нет необходимости в назначении лишних лекарственных препаратов. Учитывая широкую распространенность функциональных расстройств ЖКТ и их значительное влияние на качество жизни больных, необходим поиск новых методов профилактики и лечения данной группы патологических состояний.

Currently, in the Russian Federation, as well as throughout the world, there is an increase in allergic diseases, including an increase in the number of gastrointestinal manifestations of allergies. Moreover, along with Ig-E-mediated reactions, anaphylactoid reactions occur due to the excessive release of histamine and other biologically active substances from mast cells. These pathological processes can contribute to exacerbation of functional disorders of the gastrointestinal tract, enhancing subclinical inflammation of the mucous membrane, contributing to the development of visceral hypersensitivity and gastrointestinal motility. At the same time, most medical practitioners do not pay due attention to the possible impact of allergic and pseudo-allergic reactions on the course of irritable bowel syndrome and functional dyspepsia. At the same time, it is necessary to take into account that in the case of the syndrome of low resistance to histamine in most patients, the introduction of restrictions on the diet is sufficient and there is no need to prescribe excess drugs. Given the widespread prevalence of functional disorders of the gastrointestinal tract and their significant impact on the quality of life of patients, it is necessary to search for new methods of prevention and treatment of this group of pathological conditions.

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The authors declare that there are no conflicts of interest present.