nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-178-6-158-165nogr-1372Research ArticleОБЗОРЫREVIEWSВзаимосвязь муколитической бактерии Akkermansia muciniphila с колоректальным ракомRelationship of the mucin-degrading bacterium Akkermansia muciniphila with colorectal cancerhttps://orcid.org/0000-0002-1911-5954КарамзинА. М.KaramzinA. M.

к. б. н., доцент кафедры микробиологии, вирусологии и иммунологии Института общественного здоровья имени Ф. Ф. Эрисмана,

Москва

Cand. of Biol. Sci., Associate Professor of the Department of Microbiology, Virology and Immunology,

Moscow

karamzin_a_m@staff.sechenov.ruhttps://orcid.org/0000-0002-6939-7558РопотА. В.RopotA. V.

студент 6 курса Международной школы «Медицина будущего»,

Москва

student of the International school “Medicine of the Future”,

Moscow

https://orcid.org/0000-0003-4789-4964БошьянР. Е.BoshianR. E.

к. м. н., доцент кафедры микробиологии, вирусологии и иммунологии Института общественного здоровья имени Ф. Ф. Эрисмана,

Москва

Cand. of Med. Sci., Associate Professor of the Department of Microbiology, Virology and Immunology,

Moscow

ФГАОУ ВО Первый МГМУ им. И. М. Сеченова Минздрава России (Сеченовский Университет)РоссияI. M. Sechenov First Moscow State Medical University (Sechenov University)Russian Federation20200408202006158165Copyright © Карамзин А.М., Ропот А.В., Бошьян Р.Е., 20202020Карамзин А.М., Ропот А.В., Бошьян Р.Е.Karamzin A.M., Ropot A.V., Boshian R.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/1372

Колоректальный рак—заболевание, занимающее далеко не самое последнее место в статистике заболеваемости в Российской Федерации и в мире. Наряду с широко известными факторами риска развития данной патологии отмечается возможное участие в этом процессе некоторых представителей кишечной микробиоты. Так, в некоторых исследованиях предполагается, что с развитием колоректального рака взаимосвязана бактерия, способная расщеплять муцины,—Akkermansia muciniphila, однако другие работы подвергают это утверждение сомнению. В настоящем обзоре мы описываем ряд исследований, посвящённых определению зависимости наличия колоректального рака от количества A. muciniphila, взаимосвязи этой бактерии с развитием воспаления как предиктора онкогенеза, влиянию других представителей кишечной микробиоты на её функции, а также описываем один из возможных механизмов, связывающих способность этой бактерии расщеплять муцины с развитием онкогенеза.

Colorectal cancer is a disease that is far from the last place in the morbidity statistics in the Russian Federation and in the world. Along with well-known risk factors for the development of this pathology, some representatives of the intestinal microbiota are possible to participate in this process. Some studies suggest that Akkermansia muciniphila, a mucin-degrading bacterium, is associated with colorectal cancer development, but other studies cast doubt on this statement. In this review, we describe a series of studies devoted to determining the dependence of colorectal cancer on the amount of A. muciniphila, the relationship of this bacterium with inflammation development as a predictor of oncogenesis, the influence of other representatives of the intestinal microbiota on its function, and also describe one of the possible mechanisms linking the mucin-degraging ability of this bacterium with the development of oncogenesis.

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The authors declare that there are no conflicts of interest present.