nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-178-6-146-153nogr-1369Research ArticleОБЗОРЫREVIEWSИнфекция Helicobacter pylori и жировая инфильтрация печениHelicobacter pylori infection and fatty liverСарсенбаеваА. С.SarsenbaevаA. S.

кафедра терапии ИДПО, профессор, д. м. н.,

454092 Челябинская область, г. Челябинск, улица Воровского, 64

Department of Therapy ICPE, Professor, Doctor of Medical Sciences,

64, Vorovskogo str., Chelyabinsk, 454092

УфимцевК. А.UfimtsevK. A.

врач гастроэнтеролог гастроэнтерологического центра,

454092 Челябинская область, г. Челябинск, улица Воровского, 64

doctor gastroenterologist gastroenterological center,

64, Vorovskogo str., Chelyabinsk, 454092

ДомрачеваЕ. В.DomrachevaE. V.

аспирант кафедры терапии Института дополнительного профессионального образования,

454092 Челябинская область, г. Челябинск, улица Воровского, 64

graduate student,

64, Vorovskogo str., Chelyabinsk, 454092

agelstar.es@gmail.comЮжно-Уральский государственный медицинский университет Министерства здравоохранения Российской ФедерацииРоссияSouth-Ural State Medical UniversityRussian Federation20200308202006146153Copyright © Сарсенбаева А.С., Уфимцев К.А., Домрачева Е.В., 20202020Сарсенбаева А.С., Уфимцев К.А., Домрачева Е.В.Sarsenbaevа A.S., Ufimtsev K.A., Domracheva E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/1369

Инфекция Helicobacter pylori широко распространена во всем мире. Она играет значительную роль в патогенезе многих заболеваний желудочно-кишечного тракта, таких как язвенная болезнь, атрофический гастрит, рак желудка. За последнее время появилось большое количество работ, указывающих на связь инфекции Helicobacter pylori с экстрагастральными заболеваниями. Заболевания печени, и особенно, жировая болезнь печени, также широко распространены и активно изучаются. Связь между инфекцией Helicobacter pylori и неалкогольной жировой болезнью печени стала предметом множества исследований, однако данных все еще недостаточно для однозначных выводов.

Helicobacter pylori infection is widespread worldwide. It plays a signifi cant role in the pathogenesis of many diseases of the gastrointestinal tract, such as peptic ulcer, atrophic gastritis, and cancer of the stomach. Recently, a large number of works have appeared that indicate the association of Helicobacter pylori infection with extragastric diseases. Liver diseases, and especially fatty liver disease, are also widespread and actively studied. The association between Helicobacter pylori infection and non-alcoholic fatty liver disease has been the subject of many studies, but there is still insufficient evidence to make it clear.

неалкогольная жировая болезнь печениHelicobacter pyloriметаболический синдроминсулинорезистентностьожирениеnon-alcoholic fatty liver diseaseHelicobacter pylorimetabolic syndromeinsulin resistanceobesityReferencesMarshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984, no.1, pp.1311–1315.Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984, no.1, pp.1311–1315.Cover TL, Blaser MJ. Helicobacter pylori in health and disease. Gastroenterology. 2009, no.136, pp.1863–1873.Cover TL, Blaser MJ. Helicobacter pylori in health and disease. Gastroenterology. 2009, no.136, pp.1863–1873.Malfertheiner P, Megraud F, O’Morain CA, Atherton J, Axon AT, Bazzoli F, Gensini GF, Gisbert JP, Graham DY, Rokkas T et al. Management of Helicobacter pylori infection–the Maastricht IV/ Florence Consensus Report. Gut. 2012, no.61, pp.646–664.Malfertheiner P, Megraud F, O’Morain CA, Atherton J, Axon AT, Bazzoli F, Gensini GF, Gisbert JP, Graham DY, Rokkas T et al. Management of Helicobacter pylori infection–the Maastricht IV/ Florence Consensus Report. Gut. 2012, no.61, pp.646–664.Matsuhisa T, Aft ab H. Observation of gastric mucosa in Bangladesh, the country with the lowest incidence of gastric cancer, and Japan, the country with the highest incidence. Helicobacter. 2012, no.17, pp. 396–401.Matsuhisa T, Aft ab H. Observation of gastric mucosa in Bangladesh, the country with the lowest incidence of gastric cancer, and Japan, the country with the highest incidence. Helicobacter. 2012, no.17, pp. 396–401.Patel P, Mendall MA, Carrington D, Strachan DP, Leatham E, Molineaux N, Levy J, Blakeston C, Seymour CA, Camm AJ. Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors. BMJ. 1995, no.311, pp.711–714.Patel P, Mendall MA, Carrington D, Strachan DP, Leatham E, Molineaux N, Levy J, Blakeston C, Seymour CA, Camm AJ. Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors. BMJ. 1995, no.311, pp.711–714.Federman DG, Kirsner RS, Moriarty JP, Concato J. The effect of antibiotic therapy for patients infected with Helicobacter pylori who have chronic urticaria. J Am Acad Dermatol. 2003, no.49, pp.861–864.Federman DG, Kirsner RS, Moriarty JP, Concato J. The effect of antibiotic therapy for patients infected with Helicobacter pylori who have chronic urticaria. J Am Acad Dermatol. 2003, no.49, pp.861–864.Maurer KJ, Ihrig MM, Rogers AB, Ng V, Bouchard G, Leonard MR, Carey MC, Fox JG. Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formation. Gastroenterology. 2005, no.128, pp.1023–1033.Maurer KJ, Ihrig MM, Rogers AB, Ng V, Bouchard G, Leonard MR, Carey MC, Fox JG. Identification of cholelithogenic enterohepatic helicobacter species and their role in murine cholesterol gallstone formation. Gastroenterology. 2005, no.128, pp.1023–1033.Takahashi Y, Yamamichi N, Shimamoto T, Mochizuki S, Fujishiro M, Takeuchi C, Sakaguchi Y, Niimi K, Ono S, Kodashima S et al. Helicobacter pylori infection is positively associated with gallstones: a large-scale cross-sectional study in Japan. J Gastroenterol. 2014, no.49, pp.882–889.Takahashi Y, Yamamichi N, Shimamoto T, Mochizuki S, Fujishiro M, Takeuchi C, Sakaguchi Y, Niimi K, Ono S, Kodashima S et al. Helicobacter pylori infection is positively associated with gallstones: a large-scale cross-sectional study in Japan. J Gastroenterol. 2014, no.49, pp.882–889.Franceschi F, Zuccalà G, Roccarina D, Gasbarrini A. Clinical effects of Helicobacter pylori outside the stomach. Nat Rev Gastroenterol Hepatol. 2014, no.11, pp.234–242.Franceschi F, Zuccalà G, Roccarina D, Gasbarrini A. Clinical effects of Helicobacter pylori outside the stomach. Nat Rev Gastroenterol Hepatol. 2014, no.11, pp.234–242.Waluga M, Kukla M, Żorniak M, Bacik A, Kotulski R. From the stomach to other organs: Helicobacter pylori and the liver. World J Hepatol. 2015, no.7, pp.2136–2146.Waluga M, Kukla M, Żorniak M, Bacik A, Kotulski R. From the stomach to other organs: Helicobacter pylori and the liver. World J Hepatol. 2015, no.7, pp.2136–2146.Rabelo-Gonçalves EM, Roesler BM, Zeitune JM. Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases. World J Hepatol. 2015, no.7, pp.2968–2979.Rabelo-Gonçalves EM, Roesler BM, Zeitune JM. Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases. World J Hepatol. 2015, no.7, pp.2968–2979.de Korwin JD, Ianiro G, Gibiino G, Gasbarrini A. Helicobacter pylori infection and extragastric diseases in 2017. Helicobacter. 2017, no.22, Suppl 1.de Korwin JD, Ianiro G, Gibiino G, Gasbarrini A. Helicobacter pylori infection and extragastric diseases in 2017. Helicobacter. 2017, no.22, Suppl 1.Pietroiusti A, Diomedi M, Silvestrini M, Cupini LM, Luzzi I, Gomez-Miguel MJ, Bergamaschi A, Magrini A, Carrabs T, Vellini M et al. Cytotoxin-associated gene-A-positive Helicobacter pylori strains are associated with atherosclerotic stroke. Circulation. 2002, no.106, pp.580–584.Pietroiusti A, Diomedi M, Silvestrini M, Cupini LM, Luzzi I, Gomez-Miguel MJ, Bergamaschi A, Magrini A, Carrabs T, Vellini M et al. Cytotoxin-associated gene-A-positive Helicobacter pylori strains are associated with atherosclerotic stroke. Circulation. 2002, no.106, pp.580–584.Diomedi M, Pietroiusti A, Silvestrini M, Rizzato B, Cupini LM, Ferrante F, Magrini A, Bergamaschi A, Galante A, Bernardi G. CagA-positive Helicobacter pylori strains may influence the natural history of atherosclerotic stroke. Neurology. 2004, no.63, pp.800–804.Diomedi M, Pietroiusti A, Silvestrini M, Rizzato B, Cupini LM, Ferrante F, Magrini A, Bergamaschi A, Galante A, Bernardi G. CagA-positive Helicobacter pylori strains may influence the natural history of atherosclerotic stroke. Neurology. 2004, no.63, pp.800–804.Cho I, Blaser MJ, François F, Mathew JP, Ye XY, Goldberg JD, Bini EJ. Helicobacter pylori and overweight status in the United States: data from the Third National Health and Nutrition Examination Survey. Am J Epidemiol. 2005, no.162, pp.579–584.Cho I, Blaser MJ, François F, Mathew JP, Ye XY, Goldberg JD, Bini EJ. Helicobacter pylori and overweight status in the United States: data from the Third National Health and Nutrition Examination Survey. Am J Epidemiol. 2005, no.162, pp.579–584.Longo-Mbenza B, Nkondi Nsenga J, Vangu Ngoma D. Prevention of the metabolic syndrome insulin resistance and the atherosclerotic diseases in Africans infected by Helicobacter pylori infection and treated by antibiotics. Int J Cardiol. 2007, no.121, pp.229–238.Longo-Mbenza B, Nkondi Nsenga J, Vangu Ngoma D. Prevention of the metabolic syndrome insulin resistance and the atherosclerotic diseases in Africans infected by Helicobacter pylori infection and treated by antibiotics. Int J Cardiol. 2007, no.121, pp.229–238.Gunji T, Matsuhashi N, Sato H, Fujibayashi K, Okumura M, Sasabe N, Urabe A. Helicobacter pylori infection is signifi cantly associated with metabolic syndrome in the Japanese population. Am J Gastroenterol. 2008, no.103, pp.3005–3010.Gunji T, Matsuhashi N, Sato H, Fujibayashi K, Okumura M, Sasabe N, Urabe A. Helicobacter pylori infection is signifi cantly associated with metabolic syndrome in the Japanese population. Am J Gastroenterol. 2008, no.103, pp.3005–3010.Satoh H, Saijo Y, Yoshioka E, Tsutsui H. Helicobacter pylori infection is a signifi cant risk for modifi ed lipid profi le in Japanese male subjects. J Atheroscler Th romb. 2010, no.17, pp.1041–1048.Satoh H, Saijo Y, Yoshioka E, Tsutsui H. Helicobacter pylori infection is a signifi cant risk for modifi ed lipid profi le in Japanese male subjects. J Atheroscler Th romb. 2010, no.17, pp.1041–1048.Naja F, Nasreddine L, Hwalla N, Moghames P, Shoaib H, Fatfat M, Sibai A, Gali-Muhtasib H. Association of H. pylori infection with insulin resistance and metabolic syndrome among Lebanese adults. Helicobacter. 2012, no.17, pp.444–451.Naja F, Nasreddine L, Hwalla N, Moghames P, Shoaib H, Fatfat M, Sibai A, Gali-Muhtasib H. Association of H. pylori infection with insulin resistance and metabolic syndrome among Lebanese adults. Helicobacter. 2012, no.17, pp.444–451.Stergiopoulos C, Kountouras J, DaskalopoulouVlachoyianni E, Polyzos SA, Zavos C, Vlachoyiannis E, Kokkali S, Deretzi G, Kapetanakis N, Katsinelos P et al. Helicobacter pylori may play a role in both obstructive sleep apnea and metabolic syndrome. Sleep Med. 2012, no.13, pp.212–213.Stergiopoulos C, Kountouras J, DaskalopoulouVlachoyianni E, Polyzos SA, Zavos C, Vlachoyiannis E, Kokkali S, Deretzi G, Kapetanakis N, Katsinelos P et al. Helicobacter pylori may play a role in both obstructive sleep apnea and metabolic syndrome. Sleep Med. 2012, no.13, pp.212–213.Shin DW, Kwon HT, Kang JM, Park JH, Choi HC, Park MS, Park SM, Son KY, Cho B. Association between metabolic syndrome and Helicobacter pylori infection diagnosed by histologic status and serological status. J Clin Gastroenterol. 2012, no.46, pp.840–845.Shin DW, Kwon HT, Kang JM, Park JH, Choi HC, Park MS, Park SM, Son KY, Cho B. Association between metabolic syndrome and Helicobacter pylori infection diagnosed by histologic status and serological status. J Clin Gastroenterol. 2012, no.46, pp.840–845.Buzás GM. Metabolic consequences of Helicobacter pylori infection and eradication. World J Gastroenterol. 2014, no.20, pp.5226–5234.Buzás GM. Metabolic consequences of Helicobacter pylori infection and eradication. World J Gastroenterol. 2014, no.20, pp.5226–5234.Lee M, Baek H, Park JS, Kim S, Kyung C, Baik SJ, Lee BK, Kim JH, Ahn CW, Kim KR et al. Current Helicobacter pylori infection is significantly associated with subclinical coronary atherosclerosis in healthy subjects: A cross-sectional study. PLoS One. 2018, 13: e0193646.Lee M, Baek H, Park JS, Kim S, Kyung C, Baik SJ, Lee BK, Kim JH, Ahn CW, Kim KR et al. Current Helicobacter pylori infection is significantly associated with subclinical coronary atherosclerosis in healthy subjects: A cross-sectional study. PLoS One. 2018, 13: e0193646.Nilsson HO, Mulchandani R, Tranberg KG, Stenram U, Wadström T. Helicobacter species identified in liver from patients with cholangiocarcinoma and hepatocellular carcinoma. Gastroenterology. 2001, no.120, pp.323–324.Nilsson HO, Mulchandani R, Tranberg KG, Stenram U, Wadström T. Helicobacter species identified in liver from patients with cholangiocarcinoma and hepatocellular carcinoma. Gastroenterology. 2001, no.120, pp.323–324.Pellicano R, Mazzaferro V, Grigioni WF, Cutufi a MA, Fagoonee S, Silengo L, Rizzetto M, Ponzetto A. Helicobacter species sequences in liver samples from patients with and without hepatocellular carcinoma. World J Gastroenterol. 2004, no.10, pp.598–601.Pellicano R, Mazzaferro V, Grigioni WF, Cutufi a MA, Fagoonee S, Silengo L, Rizzetto M, Ponzetto A. Helicobacter species sequences in liver samples from patients with and without hepatocellular carcinoma. World J Gastroenterol. 2004, no.10, pp.598–601.Huang Y, Fan XG, Wang ZM, Zhou JH, Tian XF, Li N. Identification of helicobacter species in human liver samples from patients with primary hepatocellular carcinoma. J Clin Pathol. 2004, no.57, pp.1273–1277.Huang Y, Fan XG, Wang ZM, Zhou JH, Tian XF, Li N. Identification of helicobacter species in human liver samples from patients with primary hepatocellular carcinoma. J Clin Pathol. 2004, no.57, pp.1273–1277.Xuan SY, Li N, Qiang X, Zhou RR, Shi YX, Jiang WJ. Helicobacter infection in hepatocellular carcinoma tissue. World J Gastroenterol. 2006, no.12, pp.2335–2340.Xuan SY, Li N, Qiang X, Zhou RR, Shi YX, Jiang WJ. Helicobacter infection in hepatocellular carcinoma tissue. World J Gastroenterol. 2006, no.12, pp.2335–2340.Cindoruk M, Cirak MY, Unal S, Karakan T, Erkan G, Engin D, Dumlu S, Turet S. Identification of Helicobacter species by 16S rDNA PCR and sequence analysis in human liver samples from patients with various etiologies of benign liver diseases. Eur J Gastroenterol Hepatol. 2008, no.20, pp.33–36.Cindoruk M, Cirak MY, Unal S, Karakan T, Erkan G, Engin D, Dumlu S, Turet S. Identification of Helicobacter species by 16S rDNA PCR and sequence analysis in human liver samples from patients with various etiologies of benign liver diseases. Eur J Gastroenterol Hepatol. 2008, no.20, pp.33–36.Pirouz T, Zounubi L, Keivani H, Rakhshani N, Hormazdi M. Detection of Helicobacter pylori in paraffin-embedded specimens from patients with chronic liver diseases, using the amplification method. Dig Dis Sci. 2009, no.54, pp.1456–1459.Pirouz T, Zounubi L, Keivani H, Rakhshani N, Hormazdi M. Detection of Helicobacter pylori in paraffin-embedded specimens from patients with chronic liver diseases, using the amplification method. Dig Dis Sci. 2009, no.54, pp.1456–1459.Esmat G, El-Bendary M, Zakarya S, Ela MA, Zalata K. Role of Helicobacter pylori in patients with HCV-related chronic hepatitis and cirrhosis with or without hepatocellular carcinoma: possible association with disease progression. J Viral Hepat. 2012, no.19, pp.473–479.Esmat G, El-Bendary M, Zakarya S, Ela MA, Zalata K. Role of Helicobacter pylori in patients with HCV-related chronic hepatitis and cirrhosis with or without hepatocellular carcinoma: possible association with disease progression. J Viral Hepat. 2012, no.19, pp.473–479.Okushin K, Takahashi Y, Yamamichi N, Shimamoto T, Enooku K, Fujinaga H, Tsutsumi T, Shintani Y, Sakaguchi Y, Ono S, et al. Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan. BMC Gastroenterol. 2015, no.15, p.25.Okushin K, Takahashi Y, Yamamichi N, Shimamoto T, Enooku K, Fujinaga H, Tsutsumi T, Shintani Y, Sakaguchi Y, Ono S, et al. Helicobacter pylori infection is not associated with fatty liver disease including non-alcoholic fatty liver disease: a large-scale cross-sectional study in Japan. BMC Gastroenterol. 2015, no.15, p.25.Baeg MK, Yoon SK, Ko SH, Noh YS, Lee IS, Choi MG. Helicobacter pylori infection is not associated with nonalcoholic fatty liver disease. World J Gastroenterol. 2016, no.22, pp.2592–2600.Baeg MK, Yoon SK, Ko SH, Noh YS, Lee IS, Choi MG. Helicobacter pylori infection is not associated with nonalcoholic fatty liver disease. World J Gastroenterol. 2016, no.22, pp.2592–2600.Fan N, Peng L, Xia Z, Zhang L, Wang Y, Peng Y. Helicobacter pylori Infection Is Not Associated with Non-alcoholic Fatty Liver Disease: A Cross-Sectional Study in China. Front Microbiol. 2018, no.9, p.73.Fan N, Peng L, Xia Z, Zhang L, Wang Y, Peng Y. Helicobacter pylori Infection Is Not Associated with Non-alcoholic Fatty Liver Disease: A Cross-Sectional Study in China. Front Microbiol. 2018, no.9, p.73.Cai O, Huang Z, Li M, Zhang C, Xi F, Tan S. Association between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease: A Single-Center Clinical Study. Gastroenterol Res Pract. 2018; 2018:8040262.Cai O, Huang Z, Li M, Zhang C, Xi F, Tan S. Association between Helicobacter pylori Infection and Nonalcoholic Fatty Liver Disease: A Single-Center Clinical Study. Gastroenterol Res Pract. 2018; 2018:8040262.Jamali R, Mofi d A, Vahedi H, Farzaneh R, Dowlatshahi S. Th e eff ect of Helicobacter pylori eradication on liver fat content in subjects with non-alcoholic Fatty liver disease: a randomized open-label clinical trial. Hepat Mon. 2013, no.13, e14679.Jamali R, Mofi d A, Vahedi H, Farzaneh R, Dowlatshahi S. Th e eff ect of Helicobacter pylori eradication on liver fat content in subjects with non-alcoholic Fatty liver disease: a randomized open-label clinical trial. Hepat Mon. 2013, no.13, e14679.Polyzos SA, Nikolopoulos P, Stogianni A, Romiopoulos I, Katsinelos P, Kountouras J. Eff ect of Helicobacter pylori eradication on hepatic steatosis, NAFLD fi brosis score and HSENSI in patients with nonalcoholic steatohepatitis: a MR imaging-based pilot open-label study. Arq Gastroenterol. 2014, no.51, pp.261–268.Polyzos SA, Nikolopoulos P, Stogianni A, Romiopoulos I, Katsinelos P, Kountouras J. Eff ect of Helicobacter pylori eradication on hepatic steatosis, NAFLD fi brosis score and HSENSI in patients with nonalcoholic steatohepatitis: a MR imaging-based pilot open-label study. Arq Gastroenterol. 2014, no.51, pp.261–268.Polyzos SA, Kountouras J, Papatheodorou A, Patsiaoura K, Katsiki E, Zafeiriadou E, Zavos C, Anastasiadou K, Terpos E. Helicobacter pylori infection in patients with nonalcoholic fatty liver disease. Metabolism. 2013, no.62, pp.121–126.Polyzos SA, Kountouras J, Papatheodorou A, Patsiaoura K, Katsiki E, Zafeiriadou E, Zavos C, Anastasiadou K, Terpos E. Helicobacter pylori infection in patients with nonalcoholic fatty liver disease. Metabolism. 2013, no.62, pp.121–126.Doğan Z, Filik L, Ergül B, Sarikaya M, Akbal E. Association between Helicobacter pylori and liver-to-spleen ratio: a randomized-controlled single-blind study. Eur J Gastroenterol Hepatol. 2013, no.25, pp.107–110.Doğan Z, Filik L, Ergül B, Sarikaya M, Akbal E. Association between Helicobacter pylori and liver-to-spleen ratio: a randomized-controlled single-blind study. Eur J Gastroenterol Hepatol. 2013, no.25, pp.107–110.Kim TJ, Sinn DH, Min YW, Son HJ, Kim JJ, Chang Y, Baek SY, Ahn SH, Lee H, Ryu S. A cohort study on Helicobacter pylori infection associated with nonalcoholic fatty liver disease. J Gastroenterol. 2017, no.52, pp.1201–1210.Kim TJ, Sinn DH, Min YW, Son HJ, Kim JJ, Chang Y, Baek SY, Ahn SH, Lee H, Ryu S. A cohort study on Helicobacter pylori infection associated with nonalcoholic fatty liver disease. J Gastroenterol. 2017, no.52, pp.1201–1210.Chen CX, Mao YS, Foster P, Zhu ZW, Du J, Guo CY. Possible association between Helicobacter pylori infection and nonalcoholic fatty liver disease. Appl Physiol Nutr Metab. 2017, no.42, pp.295–301.Chen CX, Mao YS, Foster P, Zhu ZW, Du J, Guo CY. Possible association between Helicobacter pylori infection and nonalcoholic fatty liver disease. Appl Physiol Nutr Metab. 2017, no.42, pp.295–301.Wijarnpreecha K, Th ongprayoon C, Panjawatanan P, Manatsathit W, Jaruvongvanich V, Ungprasert P. Helicobacter pylori and Risk of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis. J Clin Gastroenterol. 2018, no.52, pp.386–391.Wijarnpreecha K, Th ongprayoon C, Panjawatanan P, Manatsathit W, Jaruvongvanich V, Ungprasert P. Helicobacter pylori and Risk of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis. J Clin Gastroenterol. 2018, no.52, pp.386–391.Refaeli R, Chodick G, Haj S, Goren S, Shalev V, Muhsen K. Relationships of H. pylori infection and its related gastroduodenal morbidity with metabolic syndrome: a large cross-sectional study. Sci Rep. 2018, no.8, p.4088.Refaeli R, Chodick G, Haj S, Goren S, Shalev V, Muhsen K. Relationships of H. pylori infection and its related gastroduodenal morbidity with metabolic syndrome: a large cross-sectional study. Sci Rep. 2018, no.8, p.4088.Upala S, Jaruvongvanich V, Riangwiwat T, Ja ru vo ngvanich S, Sanguankeo A. Association between Helicobacter pylori infection and metabolic syndrome: a systematic review and meta-analysis. J Dig Dis. 2016, no.17, pp.433–440.Upala S, Jaruvongvanich V, Riangwiwat T, Ja ru vo ngvanich S, Sanguankeo A. Association between Helicobacter pylori infection and metabolic syndrome: a systematic review and meta-analysis. J Dig Dis. 2016, no.17, pp.433–440.Chen LW, Chien CY, Yang KJ, Kuo SF, Chen CH, Chien RN. Helicobacter pylori Infection Increases Insulin Resistance and Metabolic Syndrome in Residents Younger than 50 Years Old: A Community-Based Study. PLoS One. 2015, no.10, e0128671.Chen LW, Chien CY, Yang KJ, Kuo SF, Chen CH, Chien RN. Helicobacter pylori Infection Increases Insulin Resistance and Metabolic Syndrome in Residents Younger than 50 Years Old: A Community-Based Study. PLoS One. 2015, no.10, e0128671.Chen LW, Chien CY, Hsieh CW, Chang LC, Huang MH, Huang WY, Kuo SF, Chien CH, Lin CL, Chien RN. Th e Associations Between Helicobacter pylori Infection, Serum Vitamin D, and Metabolic Syndrome: A Community-Based Study. Medicine (Baltimore) 2016, no.95, e3616.Chen LW, Chien CY, Hsieh CW, Chang LC, Huang MH, Huang WY, Kuo SF, Chien CH, Lin CL, Chien RN. Th e Associations Between Helicobacter pylori Infection, Serum Vitamin D, and Metabolic Syndrome: A Community-Based Study. Medicine (Baltimore) 2016, no.95, e3616.Gunji T, Matsuhashi N, Sato H, Fujibayashi K, Okumura M, Sasabe N, Urabe A. Helicobacter pylori infection is signifi cantly associated with metabolic syndrome in the Japanese population. Am J Gastroenterol. 2008, no.103, pp.3005–3010.Gunji T, Matsuhashi N, Sato H, Fujibayashi K, Okumura M, Sasabe N, Urabe A. Helicobacter pylori infection is signifi cantly associated with metabolic syndrome in the Japanese population. Am J Gastroenterol. 2008, no.103, pp.3005–3010.Chen TP, Hung HF, Chen MK, Lai HH, Hsu WF, Huang KC, Yang KC. Helicobacter pylori Infection is Positively Associated with Metabolic Syndrome in Taiwanese Adults: a Cross-Sectional Study. Helicobacter. 2015, no.20, pp.184–191.Chen TP, Hung HF, Chen MK, Lai HH, Hsu WF, Huang KC, Yang KC. Helicobacter pylori Infection is Positively Associated with Metabolic Syndrome in Taiwanese Adults: a Cross-Sectional Study. Helicobacter. 2015, no.20, pp.184–191.Yang W, Xuan C. Influence of Helicobacter pylori Infection on Metabolic Syndrome in Old Chinese People. Gastroenterol Res Pract. 2016; 2016:6951264.Yang W, Xuan C. Influence of Helicobacter pylori Infection on Metabolic Syndrome in Old Chinese People. Gastroenterol Res Pract. 2016; 2016:6951264.Takeoka A, Tayama J, Yamasaki H, Kobayashi M, Ogawa S, Saigo T, Hayashida M, Shirabe S. Impact of Helicobacter pylori Immunoglobulin G Levels and Atrophic Gastritis Status on Risk of Metabolic Syndrome. PLoS One. 2016, no.11, e0166588.Takeoka A, Tayama J, Yamasaki H, Kobayashi M, Ogawa S, Saigo T, Hayashida M, Shirabe S. Impact of Helicobacter pylori Immunoglobulin G Levels and Atrophic Gastritis Status on Risk of Metabolic Syndrome. PLoS One. 2016, no.11, e0166588.Woodward M, Morrison C, McColl K. An investigation into factors associated with Helicobacter pylori infection. J Clin Epidemiol. 2000, no.53, pp.175–181.Woodward M, Morrison C, McColl K. An investigation into factors associated with Helicobacter pylori infection. J Clin Epidemiol. 2000, no.53, pp.175–181.Gillum RF. Infection with Helicobacter pylori, coronary heart disease, cardiovascular risk factors, and systemic infl ammation: the Th ird National Health and Nutrition Examination Survey. J Natl Med Assoc. 2004, no.96, pp.1470–1476.Gillum RF. Infection with Helicobacter pylori, coronary heart disease, cardiovascular risk factors, and systemic infl ammation: the Th ird National Health and Nutrition Examination Survey. J Natl Med Assoc. 2004, no.96, pp.1470–1476.Mostaza JM, Camino N, Gerique JG, Peña R, Baquero M, Lahoz C. C-reactive protein levels and prevalence of chronic infections in subjects with hypoalphalipoproteinemia. Metabolism. 2005, no.54, pp.33–37.Mostaza JM, Camino N, Gerique JG, Peña R, Baquero M, Lahoz C. C-reactive protein levels and prevalence of chronic infections in subjects with hypoalphalipoproteinemia. Metabolism. 2005, no.54, pp.33–37.Sotiropoulos A, Gikas A, Skourtis S, Merkouris P, Pentzeridis P, Polydorou A, Pappas S. Seropositivity to Chlamydia pneumoniae or Helicobacter pylori and coronary artery disease. Int J Cardiol. 2006, no.109, pp.420–421.Sotiropoulos A, Gikas A, Skourtis S, Merkouris P, Pentzeridis P, Polydorou A, Pappas S. Seropositivity to Chlamydia pneumoniae or Helicobacter pylori and coronary artery disease. Int J Cardiol. 2006, no.109, pp.420–421.Alzahrani S, Nelson J, Moss SF, Paulus JK, Knowler WC, Pittas AG; Diabetes Prevention Program Research Group. H. pylori seroprevalence and risk of diabetes: An ancillary case-control study nested in the diabetes prevention program. J Diabetes Complications. 2017, no.31, pp.1515–1520.Alzahrani S, Nelson J, Moss SF, Paulus JK, Knowler WC, Pittas AG; Diabetes Prevention Program Research Group. H. pylori seroprevalence and risk of diabetes: An ancillary case-control study nested in the diabetes prevention program. J Diabetes Complications. 2017, no.31, pp.1515–1520.Lender N, Talley NJ, Enck P, Haag S, Zipfel S, Morrison M, Holtmann GJ. Review article: Associations between Helicobacter pylori and obesity-an ecological study. Aliment Pharmacol Th er. 2014, no.40, pp.24–31.Lender N, Talley NJ, Enck P, Haag S, Zipfel S, Morrison M, Holtmann GJ. Review article: Associations between Helicobacter pylori and obesity-an ecological study. Aliment Pharmacol Th er. 2014, no.40, pp.24–31.Xu C, Yan M, Sun Y, Joo J, Wan X, Yu C, Wang Q, Shen C, Chen P, Li Y et al. Prevalence of Helicobacter pylori infection and its relation with body mass index in a Chinese population. Helicobacter. 2014, no.19, pp.437–442.Xu C, Yan M, Sun Y, Joo J, Wan X, Yu C, Wang Q, Shen C, Chen P, Li Y et al. Prevalence of Helicobacter pylori infection and its relation with body mass index in a Chinese population. Helicobacter. 2014, no.19, pp.437–442.Zhang Y, Du T, Chen X, Yu X, Tu L, Zhang C. Association between Helicobacter pylori infection and overweight or obesity in a Chinese population. J Infect Dev Ctries. 2015, no.9, pp.945–953.Zhang Y, Du T, Chen X, Yu X, Tu L, Zhang C. Association between Helicobacter pylori infection and overweight or obesity in a Chinese population. J Infect Dev Ctries. 2015, no.9, pp.945–953.Nwokolo CU, Freshwater DA, O’Hare P, Randeva HS. Plasma ghrelin following cure of Helicobacter pylori. Gut. 2003, no.52, pp.637–640.Nwokolo CU, Freshwater DA, O’Hare P, Randeva HS. Plasma ghrelin following cure of Helicobacter pylori. Gut. 2003, no.52, pp.637–640.Inui A, Asakawa A, Bowers CY, Mantovani G, Laviano A, Meguid MM, Fujimiya M. Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ. FASEB J. 2004, no.18, pp.439–456.Inui A, Asakawa A, Bowers CY, Mantovani G, Laviano A, Meguid MM, Fujimiya M. Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ. FASEB J. 2004, no.18, pp.439–456.Chitturi S, Abeygunasekera S, Farrell GC, Holmes-Walker J, Hui JM, Fung C, Karim R, Lin R, Samarasinghe D, Liddle C et al. NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology. 2002, no.35, pp.373–379.Chitturi S, Abeygunasekera S, Farrell GC, Holmes-Walker J, Hui JM, Fung C, Karim R, Lin R, Samarasinghe D, Liddle C et al. NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology. 2002, no.35, pp.373–379.Chen LW, Chien CY, Yang KJ, Kuo SF, Chen CH, Chien RN. Helicobacter pylori Infection Increases Insulin Resistance and Metabolic Syndrome in Residents Younger than 50 Years Old: A Community-Based Study. PLoS One. 2015, no.10, e0128671.Chen LW, Chien CY, Yang KJ, Kuo SF, Chen CH, Chien RN. Helicobacter pylori Infection Increases Insulin Resistance and Metabolic Syndrome in Residents Younger than 50 Years Old: A Community-Based Study. PLoS One. 2015, no.10, e0128671.Eshraghian A, Hashemi SA, Hamidian Jahromi A, Eshraghian H, Masoompour SM, Davarpanah MA, Eshraghian K, Taghavi SA. Helicobacter pylori infection as a risk factor for insulin resistance. Dig Dis Sci. 2009, no.54, pp.1966–1970.Eshraghian A, Hashemi SA, Hamidian Jahromi A, Eshraghian H, Masoompour SM, Davarpanah MA, Eshraghian K, Taghavi SA. Helicobacter pylori infection as a risk factor for insulin resistance. Dig Dis Sci. 2009, no.54, pp.1966–1970.Gunji T, Matsuhashi N, Sato H, Fujibayashi K, Okumura M, Sasabe N, Urabe A. Helicobacter pylori infection signifi cantly increases insulin resistance in the asymptomatic Japanese population. Helicobacter. 2009, no.14, pp.144–150.Gunji T, Matsuhashi N, Sato H, Fujibayashi K, Okumura M, Sasabe N, Urabe A. Helicobacter pylori infection signifi cantly increases insulin resistance in the asymptomatic Japanese population. Helicobacter. 2009, no.14, pp.144–150.Polyzos SA, Kountouras J, Zavos C, Deretzi G. Th e association between Helicobacter pylori infection and insulin resistance: a systematic review. Helicobacter. 2011, no.16, pp.79–88.Polyzos SA, Kountouras J, Zavos C, Deretzi G. Th e association between Helicobacter pylori infection and insulin resistance: a systematic review. Helicobacter. 2011, no.16, pp.79–88.Polyzos SA, Kountouras J, Zavos C, Deretzi G. Helicobacter pylori Infection and insulin resistance. Helicobacter. 2013, no.18, pp.165–166.Polyzos SA, Kountouras J, Zavos C, Deretzi G. Helicobacter pylori Infection and insulin resistance. Helicobacter. 2013, no.18, pp.165–166.Naja F, Nasreddine L, Hwalla N, Moghames P, Shoaib H, Fatfat M, Sibai A, Gali-Muhtasib H. Association of H. pylori infection with insulin resistance and metabolic syndrome among Lebanese adults. Helicobacter. 2012, no.17, pp.444–451.Naja F, Nasreddine L, Hwalla N, Moghames P, Shoaib H, Fatfat M, Sibai A, Gali-Muhtasib H. Association of H. pylori infection with insulin resistance and metabolic syndrome among Lebanese adults. Helicobacter. 2012, no.17, pp.444–451.Sumida Y, Kanemasa K, Imai S, Mori K, Tanaka S, Shimokobe H, Kitamura Y, Fukumoto K, Kakutani A, Ohno T et al. Helicobacter pylori infection might have a potential role in hepatocyte ballooning in nonalcoholic fatty liver disease. J Gastroenterol. 2015, no.50, pp.996–1004.Sumida Y, Kanemasa K, Imai S, Mori K, Tanaka S, Shimokobe H, Kitamura Y, Fukumoto K, Kakutani A, Ohno T et al. Helicobacter pylori infection might have a potential role in hepatocyte ballooning in nonalcoholic fatty liver disease. J Gastroenterol. 2015, no.50, pp.996–1004.Peek RM Jr, Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer. 2002, no.2, pp.28–37.Peek RM Jr, Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer. 2002, no.2, pp.28–37.Basso D, Plebani M, Kusters JG. Pathogenesis of Helicobacter pylori infection. Helicobacter. 2010, no.15, Suppl 1, pp.14–20.Basso D, Plebani M, Kusters JG. Pathogenesis of Helicobacter pylori infection. Helicobacter. 2010, no.15, Suppl 1, pp.14–20.Feinstein R, Kanety H, Papa MZ, Lunenfeld B, Karasik A. Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J Biol Chem. 1993, no.268, pp.26055–26058.Feinstein R, Kanety H, Papa MZ, Lunenfeld B, Karasik A. Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J Biol Chem. 1993, no.268, pp.26055–26058.Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993, no.259, pp.87–91.Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993, no.259, pp.87–91.Buechler C, Wanninger J, Neumeier M. Adiponectin, a key adipokine in obesity related liver diseases. World J Gastroenterol. 2011, no.17, pp.2801–2811.Buechler C, Wanninger J, Neumeier M. Adiponectin, a key adipokine in obesity related liver diseases. World J Gastroenterol. 2011, no.17, pp.2801–2811.Ando T, Ishikawa T, Takagi T, Imamoto E, Kishimoto E, Okajima A, Uchiyama K, Handa O, Yagi N, Kokura S et al. Impact of Helicobacter pylori eradication on circulating adiponectin in humans. Helicobacter. 2013, no.18, pp.158–164.Ando T, Ishikawa T, Takagi T, Imamoto E, Kishimoto E, Okajima A, Uchiyama K, Handa O, Yagi N, Kokura S et al. Impact of Helicobacter pylori eradication on circulating adiponectin in humans. Helicobacter. 2013, no.18, pp.158–164.Stefan N, Fritsche A, Weikert C, Boeing H, Joost HG, Häring HU, Schulze MB. Plasma fetuin-A levels and the risk of type 2 diabetes. Diabetes. 2008, no.57, pp.2762–2767.Stefan N, Fritsche A, Weikert C, Boeing H, Joost HG, Häring HU, Schulze MB. Plasma fetuin-A levels and the risk of type 2 diabetes. Diabetes. 2008, no.57, pp.2762–2767.Kantartzis K, Machann J, Schick F, Fritsche A, Häring HU, Stefan N. Th e impact of liver fat vs visceral fat in determining categories of prediabetes. Diabetologia. 2010, no.53, pp.882–889.Kantartzis K, Machann J, Schick F, Fritsche A, Häring HU, Stefan N. Th e impact of liver fat vs visceral fat in determining categories of prediabetes. Diabetologia. 2010, no.53, pp.882–889.Manolakis AC, Tiaka EK, Kapsoritakis AN, Georgoulias P, Tsiopoulos F, Valotassiou V, Potamianos SP. Increased fetuin A levels in Helicobacter pylori infection: a missing link between H. pylori and insulin resistance? Diabetologia. 2011, no.54, pp.472–474.Manolakis AC, Tiaka EK, Kapsoritakis AN, Georgoulias P, Tsiopoulos F, Valotassiou V, Potamianos SP. Increased fetuin A levels in Helicobacter pylori infection: a missing link between H. pylori and insulin resistance? Diabetologia. 2011, no.54, pp.472–474.

The authors declare that there are no conflicts of interest present.