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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-178-6-112-118</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-1362</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL GASTROENTEROLOGY</subject></subj-group></article-categories><title-group><article-title>Гастроинтестинальные симптомы мигрени у детей и подростков</article-title><trans-title-group xml:lang="en"><trans-title>Gastrointestinal symptoms of migraine in children and adolescents</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7362-5843</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сероусова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Serousova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к. м. н., доцент кафедры нервных болезней,</p><p> 454092 Челябинская область, г. Челябинск, улица Воровского, 64</p></bio><bio xml:lang="en"><p>Associate Professor of the Department of Nervous Diseases, Cand. of Med. Sci.,</p><p>64, Vorovskogo str., Chelyabinsk, 454092</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5848-7235</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпова</surname><given-names>М. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpova</surname><given-names>M. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., доцент, заведующий кафедрой нервных болезней,</p><p> 454092 Челябинская область, г. Челябинск, улица Воровского, 64</p></bio><bio xml:lang="en"><p>Head of the Department of Nervous Diseases, MD,</p><p>64, Vorovskogo str., Chelyabinsk, 454092</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2569-1699</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Долгушина</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Dolgushina</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д. м. н., доцент, заведующий кафедрой госпитальной терапии,</p><p> 454092 Челябинская область, г. Челябинск, улица Воровского, 64</p></bio><bio xml:lang="en"><p>Head of the Department of Hospital Therapy, MD,</p><p>64, Vorovskogo str., Chelyabinsk, 454092</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6439-7823</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куликова</surname><given-names>Д. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulikova</surname><given-names>D. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>студентка 5 курса,</p><p> 454092 Челябинская область, г. Челябинск, улица Воровского, 64</p></bio><bio xml:lang="en"><p>5 year student,</p><p>64, Vorovskogo str., Chelyabinsk, 454092</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Южно-Уральский государственный медицинский университет Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>South-Ural State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>03</day><month>08</month><year>2020</year></pub-date><volume>0</volume><issue>6</issue><fpage>112</fpage><lpage>118</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сероусова О.В., Карпова М.И., Долгушина А.И., Куликова Д.Б., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Сероусова О.В., Карпова М.И., Долгушина А.И., Куликова Д.Б.</copyright-holder><copyright-holder xml:lang="en">Serousova O.V., Karpova M.I., Dolgushina A.I., Kulikova D.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/1362">https://www.nogr.org/jour/article/view/1362</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: изучение особенностей, частоты встречаемости и клинического значения тошноты, рвоты, абдоминальной боли, ассоциированных с приступом мигрени, у пациентов детского и подросткового возраста.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Включено 32 пациента в возрасте от 7 лет до 18 лет с диагнозом эпизодической мигрени. У всех больных тщательно анализировались тошнота, рвота и абдоминальная боль, сопровождающие атаку мигрени.</p></sec><sec><title>Результаты</title><p>Результаты. Тошнота беспокоила 78% пациентов, медиана ее интенсивности соответствовала выраженной. Рвота сопровождала атаки у 68%, медиана ее количества—3 в сутки. Приступные боли в животе развивались у 6% пациентов. При этом ранний дебют мигренозных приступов ассоциирован с выраженной тошнотой и рвотой (p=0,015 и p=0,043 соответственно). Среди пациентов мужского пола были получены прямые корреляции между интенсивностью головной боли и интенсивностью тошноты (rS=0,456, p=0,029, n=23) и количеством рвоты (rS=0,417, p=0,048, n=23).</p></sec><sec><title>Заключение</title><p>Заключение.</p></sec><sec><title>1</title><p>1. При мигрени у детей и подростков тошнота и рвота часто встречаются в качестве ассоциированных с приступом симптомов, в то время как абдоминальная боль является редким проявлением мигренозной атаки.</p></sec><sec><title>2</title><p>2. Наблюдается отрицательная взаимосвязь между возрастом пациента и интенсивностью рвоты, ранний дебют мигренозных приступов чаще сопряжен с выраженной тошнотой и рвотой, а у пациентов мужского пола интенсивность головной боли прямо коррелирует с интенсивностью тошноты и количеством рвоты.</p></sec><sec><title>3</title><p>3. Не выявлено зависимости гастроинтестинальных проявлений от пола пациента, наличия ауры при приступе, частоты атак и количества болевых дней. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Objective</title><p>Objective: to study the characteristics, frequency of occurrence, and clinical signifi cance of nausea, vomiting, abdominal pain associated with a migraine attack, in children and adolescents.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. Included 32 patients aged 7 years to 18 years with a diagnosis of episodic migraine. All patients were carefully analyzed for nausea, vomiting, and abdominal pain accompanying a migraine attack.</p></sec><sec><title>Results</title><p>Results. Nausea bothered 78% of patients, the median of its intensity corresponded to pronounced. Vomiting accompanied attacks in 68%, the median of its quantity—3 per day. Attack pain in the abdomen developed in 6% of patients. Moreover, the early onset of migraine seizures is associated with severe nausea and vomiting (p = 0,015 and p = 0,043, respectively). Among male patients, direct correlations were obtained between headache intensity and nausea intensity (rS = 0,456, p = 0,029, n = 23) and the amount of vomiting (rS = 0,417, p = 0,048, n = 23).</p></sec><sec><title>Conclusion</title><p>Conclusion.</p></sec><sec><title>1</title><p>1. With migraine in children and adolescents, nausea and vomiting are often seen as symptoms associated with an attack, while abdominal pain is a rare manifestation of a migraine attack.</p></sec><sec><title>2</title><p>2. There is a negative relationship between the age of the patient and the intensity of vomiting, the early onset of migraine attacks is often associated with severe nausea and vomiting, and in male patients, the intensity of the headache directly correlates with the intensity of nausea and the amount of vomiting.</p></sec><sec><title>3</title><p>3. There was no dependence of gastrointestinal manifestations on the patient’s gender, the presence of an aura during an attack, the frequency of attacks and the number of pain days. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>мигрень</kwd><kwd>дети</kwd><kwd>подростки</kwd><kwd>тошнота</kwd><kwd>рвота</kwd><kwd>абдоминальная боль</kwd></kwd-group><kwd-group xml:lang="en"><kwd>migraine</kwd><kwd>children</kwd><kwd>adolescents</kwd><kwd>nausea</kwd><kwd>vomiting</kwd><kwd>abdominal pain</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Feigin V. L., Abajobir A. A., Abate K. H. et al. Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 // The Lancet Neurology. – 2017. – Vol.16, № 11. – P. 877–897.</mixed-citation><mixed-citation xml:lang="en">Feigin V. L., Abajobir A. 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