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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-176-4-77-82</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-1308</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL GASTROENTEROLOGY</subject></subj-group></article-categories><title-group><article-title>Ретроспективный анализ распространенности, особенностей течения, лечения и исходов дивертикулярной болезни по данным многопрофильного стационара</article-title><trans-title-group xml:lang="en"><trans-title>Retrospective analysis of the prevalence, characteristics, therapy and outcomes of diverticular disease according to the data of a multidisciplinary hospital</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ардатская</surname><given-names>М. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Ardatskaya</surname><given-names>M. D.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"><p>Doctor of Medical Science, professor, professor of gastroenterology department</p><p>Scopus Author ID: 8713439300 Moscow</p></bio><email xlink:type="simple">ma@uni-med.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Подставкина</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Podstavkina</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мордасова</surname><given-names>В. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Mordasova</surname><given-names>V. I.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коротких</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Korotkikh</surname><given-names>N. N.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гарушьян</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Garushyan</surname><given-names>G. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central State Medical Academy of the Administrative Department of the President of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>БУЗ Воронежской области «Воронежская областная клиническая больница № 1»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Budgetary institution of health care “Voronezh regional clinical hospital № 1”</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГКУЗ «ГВКГ войск национальной гвардии»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central Military Clinical Hospital of National Guard</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>24</day><month>06</month><year>2020</year></pub-date><volume>174</volume><issue>4</issue><fpage>77</fpage><lpage>82</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ардатская М.Д., Подставкина И.С., Мордасова В.И., Коротких Н.Н., Гарушьян Г.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Ардатская М.Д., Подставкина И.С., Мордасова В.И., Коротких Н.Н., Гарушьян Г.В.</copyright-holder><copyright-holder xml:lang="en">Ardatskaya M.D., Podstavkina I.S., Mordasova V.I., Korotkikh N.N., Garushyan G.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/1308">https://www.nogr.org/jour/article/view/1308</self-uri><abstract><sec><title>Цель</title><p>Цель: изучить распространенность, особенности течения, лечение и исходы ДБ по данным многопрофильногостационара.</p></sec><sec><title>Методы исследования</title><p>Методы исследования: проведен ретроспективный анализ лечения 50 пациентов с ДБ, находившихся на лечении в БУЗ ВО «Воронежская областная клиническая больница № 1» с 2016 по 2018 гг. по следующим характеристикам: возраст и пол пациента, количество предыдущих госпитализаций, связанных с ДБ и осложнениями дивертикулеза, результаты клинико-диагностического и инструментального обследований, данные консервативного лечения и оперативных вмешательств.</p></sec><sec><title>Результаты исследования</title><p>Результаты исследования: Из 50 исследованных историй болезни 38 (79,1%) случаев были экстренного и 12 (20,9%) — планового поступления. Установлены гендерные различия с преобладанием пациентов женского пола: 28 женщин (56%) и 22 мужчин (44%). Из них: 4 больных до 30 лет (8%), 7 — от 31 до 40 лет (14%), 13 — от 41 до 50 лет (26%), 17 — от 51 до 60 лет (34%), 9 человек старше 61 года (18%). Средний возраст составил (39,2 ± 2,1) лет. Наибольшее количество пациентов находились в трудоспособном возрасте. Острый дивертикулит преобладал среди других форм ДБ — 28 (56%) пациентов. Кровотечение выявлено у 2 (4%) пациентов, перидивертикулярный инфильтрат — у 4 (8%), перидивертикулярный абсцесс — у 3 (6%), рецидивирующее течение хронического дивертикулита — у 13 (26%). Повторное развитие осложнений ДБ за трехлетний период наблюдения установлено у 40 (80%) пациентов. Из 28 (56%) пациентов с острым дивертикулитом, не получавших противорецидивное лечение, 21 человек (42%) впоследствии прооперирован по поводу осложнений ДБ.</p></sec><sec><title>Выводы</title><p>Выводы: 1. Результаты проведенного ретроспективного анализа показали, что каждый второй пациент находился в трудоспособном возрасте (до 68 лет). За период 2016–2018 гг. отмечена тенденция роста заболеваемости ДБ у пациентов всех возрастных групп.2. Острый дивертикулит преобладал среди других форм ДБ (56%). Перидивертикулярный инфильтрат и перидивертикулярный абсцесс составили 8% и 6% соответственно.3. В течение трех лет повторное развитие осложнений ДБ отмечено у 40 (80%) пациентов изучаемой выборки. Из 28 пациентов (56%) с острым дивертикулитом, пролеченных консервативно и не получавших противорецидивную терапию, 21 человек (42%) впоследствии прооперирован по поводу осложнений ДБ.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim of investigation</title><p>Aim of investigation: to study the prevalence, characteristics, therapy and outcomes of diverticular disease (DD) according to the data of a multidisciplinary hospital.</p></sec><sec><title>Material and methods</title><p>Material and methods: the retrospective survey included 50 patients treated in the Voronezh Region Clinical Hospital № 1 in the period from 2016 to 2018 according to the following characteristics: age and gender, number of previous hospitalizations associated with DD and complications of diverticulosis,  the results of clinical diagnostic and instrumental examination data, conservative treatment and surgical interventions.</p></sec><sec><title>Results</title><p>Results: Within the discovered data there were 38 (79.1%) emergency and 12 (20.9%) planned admissions. Gender diff erences were established with the predominance of female patients: 28 women (56%) and 22 men (44%) respectively. According to age diff erences 4 patients were under 30 years (8%), 7 — from 31 to 40 years (14%), 13 — from 41 to 50 years (26%), 17 — from 51 to 60 years (34%), 9 people were older than 61 years (18%). The average age was 39.2 ± 2.1 years.The majority of patients were of working age. Acute diverticulitis was the predominant form of DB — 28 (56%) cases. Bleeding was detected in 2 (4%) cases, peridiverticular infi ltrate — in 4 (8%) cases, peridiverticular abscess — in 3 (6%) cases, and recurrent chronic diverticulitis — in 13(26%) cases. Repeated development of DD complications over a three-year follow — up period was found in 40 (80%) patients. Of the 28 (56%) patients with acute diverticulitis who did not receive anti-relapse treatment, 21 (42%) were subsequently operated on for DD complications.</p></sec><sec><title>Conclusion</title><p>Conclusion: 1. The results of the performed analysis showed that every second patient with DD was of working age (up to 68 years). In the period from 2016 to 2018, there was a tendency of increase in the incidence of DD in patients of all age groups. </p></sec><sec><title>2</title><p>2. Acute diverticulitis was the predominant form of DB (56%). Peridiverticular infi ltrate and peridiverticular abscess were detected in 8% and 6% of cases respectively.</p></sec><sec><title>3</title><p>3. Within three years, repeated development of DD complications was observed in 40 (80%) patients of the studied sample. Of the 28 patients (56%) with acute diverticulitis treated conservatively and not receiving anti-relapse therapy, 21 people (42%) were subsequently operated on for complications of DD. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>дивертикулярная болезнь</kwd><kwd>дивертикулит</kwd><kwd>осложнения дивертикулярной болезни</kwd><kwd>толстый кишечник</kwd></kwd-group><kwd-group xml:lang="en"><kwd>diverticular disease</kwd><kwd>diverticulitis</kwd><kwd>complications of diverticular disease</kwd><kwd>colon</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Воробьев Г. И. Основы колопроктологии. – М., 2006. – 432 с.</mixed-citation><mixed-citation xml:lang="en">Vorobyev G. I. Osnovi koloproktologii. – Мoscow, 2006. 432 p. (In Russian)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Tursi A. Diverticulosis today: unfashionable and still underresearched. Therap Adv Gastroenterol. 2016; 9:213–228.</mixed-citation><mixed-citation xml:lang="en">Tursi A. Diverticulosis today: unfashionable and still underresearched. Therap Adv Gastroenterol. 2016; 9:213–228.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ардатская М. Д. Дивертикулярная болезнь толстой кишки // Медицинский совет. – 2017. – № 15.–С. 68–75.</mixed-citation><mixed-citation xml:lang="en">Ardatskaya M. D. Diverticular disease of the colon: resolved and unresolved issues. Medical Council. 2017;15: 68–75. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Голованова Е. В. Циклическая терапия симптоматической дивертикулярной болезни рифаксимином и растворимыми пищевыми волокнами: эффективная профилактика осложнений // Медицинский совет. – 2019. – № 3. – С. 98–107</mixed-citation><mixed-citation xml:lang="en">Golovanova E. V. Cyclic rifaximin and soluble dietary fiber therapy for symptomatic diverticular disease: effective prevention of complications. Medical Council. 2019; 3: 98–107. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ивашкин В.Т., Шелыгин Ю. А., Ачкасов С. И., Ва сильев С. В., Григорьев Е. Г., Дудка В. В., Жуков Б. Н., Карпу хин О. Ю., Кузьминов А. М., Куликовский В. Ф., Лапина Т. Л., Лахин А. В., Маев И. В., Москалев А. И., Муравьев А. В., Половинкин В. В., Полуэктова Е. А., Стойко Ю. М., Тимербулатов В. М., Трухманов А. С., Фролов С. А., Чибисов Г. И., Шифрин О. С., Шептулин А. А.,</mixed-citation><mixed-citation xml:lang="en">Ivashkin V. T., Shelygin Yu.A., Achkasov S. I., et al. Diagnostics and treatment of diverticular disease of the colon: guidelines of the Russian gastroenterological Association and Russian Association of Coloproctology. RJGHC. 2016; 1: 65–80. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Халиф И. Л., Эфрон А. Г., Яновой В. В. Рекомендации Российской гастроэнтерологической ассоциации и Ассоциации колопроктологов России по диагностике и лечению взрослых больных дивертикулярной болезнью ободочной кишки // РЖГГК. – 2016. – № 1.–С. 65–80</mixed-citation><mixed-citation xml:lang="en">Francis N.K., Sylla P., Abou Khalil M, et al. EAES and SAGES2018 consensus conference on acute diverticulitis management: evidence based recommendations for clinical practice. Surgical Endoscopy. 2019; 33: 2726–2741.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Francis N.K., Sylla P., Abou Khalil M, et al. EAES and SAGES2018 consensus conference on acute diverticulitis management: evidence based recommendations for clinical practice. Surgical Endoscopy. 2019; 33: 2726–2741.</mixed-citation><mixed-citation xml:lang="en">Jamal Talabani A, Lydersen S, Endreseth BH, Edna TH Major increase in admission- and incidence rates of acute colonic diverticulitis. Int J Colorectal Dis. 2014; 29 (8):937–45.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Jamal Talabani A, Lydersen S, Endreseth BH, Edna TH Major increase in admission- and incidence rates of acute colonic diverticulitis. Int J Colorectal Dis. 2014; 29 (8):937–45.</mixed-citation><mixed-citation xml:lang="en">Etzioni D.A., Mack T. M., Beart R. W., et al. Diverticulitis in the United States: 1998–2005. Changing patterns of disease and treatment. Ann Surg. 2009; 249(2): 210–7.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Etzioni D.A., Mack T. M., Beart R. W., et al. Diverticulitis in the United States: 1998–2005. Changing patterns of disease and treatment. Ann Surg. 2009; 249(2): 210–7.</mixed-citation><mixed-citation xml:lang="en">Tursi A., Scarpignato C., Brandimarte G., Di Mario F., Lanas A. Rifaximin for the management of colonic diverticular disease: Far beyond a simple antibiotic. J Gastrointestin Liver Dis. 2018; 27(4): 351–355.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Tursi A., Scarpignato C., Brandimarte G., Di Mario F., Lanas A. Rifaximin for the management of colonic diverticular disease: Far beyond a simple antibiotic. J Gastrointestin Liver Dis. 2018; 27(4): 351–355.</mixed-citation><mixed-citation xml:lang="en">Quigley E. M. M. Gut Microbiota, Infl ammation and Symptomatic Diverticular Disease. New Insights into an Old and Neglected Disorder. Journal of gastrointestinal and liver diseases. 2010; 19: 127–129.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Quigley E. M. M. Gut Microbiota, Infl ammation and Symptomatic Diverticular Disease. New Insights into an Old and Neglected Disorder. Journal of gastrointestinal and liver diseases. 2010; 19: 127–129.</mixed-citation><mixed-citation xml:lang="en">Timerbulatov M. V., Kulyapin A. V., Lopatin D. V. A retrospective analysis of the treatment of patients with inflammatory complications of diverticular disease of the colon. Bashkortostan Medical Journal. 2017, vol.12, no. 4 (70), pp. 5–9. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Тимербулатов М.В., Куляпин А. В., Лопатин Д. В. Ретроспективный анализ лечения пациентов с воспалительными осложнениями дивертикулярной болезни толстой кишки // Медицинский вестник Башкортостана. – 2017. – том 12. – № 4 (70). – С. 5–9</mixed-citation><mixed-citation xml:lang="en">Yamada E., Inamori M., Uchida E. et al. Association between the location of diverticular disease and the irritable bowel syndrome: a multicenter study in Japan. Am J Gastroenterol. 2014; 109: 1900–1905.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Yamada E., Inamori M., Uchida E. et al. Association between the location of diverticular disease and the irritable bowel syndrome: a multicenter study in Japan. Am J Gastroenterol. 2014; 109: 1900–1905.</mixed-citation><mixed-citation xml:lang="en">Kruchinina М. А. Diverticularnaya bolezn’ Tolstoy kishki: lecheniye I profi laktika oslozhneniy v usloviyakh polikliniki. Diss. kand. med. nauk [Diverticular colon disease: diagnosis, treatment, and prevention of exacerbations in a polyclinic. Candidate diss.]. Мoscow, 2015. 166 p. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Кручинина М. А. Дивертикулярная болезнь толстой кишки: диагностика, лечение, профилактика обострений в условиях поликлиники. Дисс. …канд. мед. наук. – М., 2015. – 166 с.</mixed-citation><mixed-citation xml:lang="en">Bolokhov K. V. Ostriye vospalitel’niye oslozhneniya diverticularnoy bolezni obodochnoy kishki (klinika, diagnostika, lecheniye). Avtoreferat diss. kand. med. nauk [Acute inflammatory complications of diverticular colon disease (clinic, diagnosis, treatment). Candidate diss.]. Мoscow, 2006. 30 p. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Болихов К. В. Острые воспалительные осложнения дивертикулярной болезни ободочной кишки (клиника, диагностика, лечение). Автореферат дисс. … канд. мед. наук. – М., 2006. – 30 с.</mixed-citation><mixed-citation xml:lang="en">Timerbulatov M. V. Diverticularnaya bolezn’ tolstoy kishki. – Мoscow, Medicinskaya kniga, 2016. 215 p. (In Russian).</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Тимербулатов В. М. Дивертикулярная болезнь толстой кишки. – М.: Медицинская книга, 2016. – 215 с.</mixed-citation><mixed-citation xml:lang="en">Тимербулатов В. М. Дивертикулярная болезнь толстой кишки. – М.: Медицинская книга, 2016. – 215 с.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
