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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nogr</journal-id><journal-title-group><journal-title xml:lang="ru">Экспериментальная и клиническая гастроэнтерология</journal-title><trans-title-group xml:lang="en"><trans-title>Experimental and Clinical Gastroenterology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-8658</issn><publisher><publisher-name>«Global Media Technologies»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/1682-8658-ecg-169-9-97-100</article-id><article-id custom-type="elpub" pub-id-type="custom">nogr-1239</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASES</subject></subj-group></article-categories><title-group><article-title>Афтозный стоматит как дебют болезни Крона</article-title><trans-title-group xml:lang="en"><trans-title>Aphthous stomatitis as the debut of Crohn’s disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9370-4768</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гаус</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gaus</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гаус Ольга Владимировна, к. м. н., доцент кафедры факультетской терапии, профессиональных болезней, Россия, 644043, г. Омск, ул. Ленина, д. 12</p></bio><bio xml:lang="en"><p>Olga V. Gaus, Cand. Sci. (Med.), Associate Professor of the Department of Faculty Therapy, Occupational Diseases, 12 Lenina street, 644043 Omsk, Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7603-8481</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахмедов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Akhmedov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ахмедов Вадим Адильевич, д. м. н., профессор, заведующий кафедрой медицинской реабилитации ДПО, Россия, 644043, г. Омск, ул. Ленина, д. 12</p></bio><bio xml:lang="en"><p>Vadim A. Akhmedov, D. Sci. (Med.), Professor, Head of the Department of of Medical Rehabilitation of Postgraduate Education, 12 Lenina street, 644043 Omsk, Russia</p></bio><email xlink:type="simple">v_akhmedov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коршунов</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Korshunov</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Коршунов Андрей Сергеевич, ассистент кафедры челюстной-лицевой хирургии, Россия, 644043, г. Омск, ул. Ленина, д. 12</p></bio><bio xml:lang="en"><p>Andrey S. Korshunov, Assistant of the Department of Oral and Maxillofacial Surgery, 12 Lenina street, 644043 Omsk, Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Омский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Educational Establishment of Higher Education Omsk State Medical University of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>24</day><month>03</month><year>2020</year></pub-date><volume>0</volume><issue>9</issue><fpage>97</fpage><lpage>100</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гаус О.В., Ахмедов В.А., Коршунов А.С., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Гаус О.В., Ахмедов В.А., Коршунов А.С.</copyright-holder><copyright-holder xml:lang="en">Gaus O.V., Akhmedov V.A., Korshunov A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.nogr.org/jour/article/view/1239">https://www.nogr.org/jour/article/view/1239</self-uri><abstract><p>Болезнь Крона иммуноопосредованное заболевание, характеризующееся неспецифическим гранулематозным трансмуральным воспалением с сегментарным поражением любого отдела желудочно-кишечного тракта с формированием внекишечных и системных осложнений. Представлено клиническое наблюдение пациента И., 23 года, студента, который был направлен на консультацию к гастроэнтерологу по направлению от стоматолога. Активных жалоб со стороны желудочно-кишечного тракта при осмотре не предъявлял. Считает себя больным в течение 6 месяцев, когда впервые появились жалобы на боль в области шеи, першение в горле, повышение температуры тела до 37,4–37,5 °C преимущественно в вечернее время. Проводилось лечение у оториноларинголога и стоматолога без существенного эффекта. В связи с чем была проведена биопсия язвенного дефекта левой ретромолярной области, выявившая неказеозное гранулематозное воспаление. Последующее обследование у гастроэнтеролога с проведением колоноскопии и биопсии позволило установить болезнь Крона как истинную причины афтозного стоматита.</p></abstract><trans-abstract xml:lang="en"><p>Crohn’s disease is an immune-mediated disease characterized by non-specific granulomatous transmural inflammation with segmental damage to any part of the gastrointestinal tract with the formation of extraintestinal and systemic complications. Clinical observation of patient I., 23 years old, a student who was sent for consultation to a gastroenterologist in the direction of a dentist, is presented. Active examination of the gastrointestinal tract during the inspection did not show any complaints. He considers himself ill for 6 months, when he first complained of pain in the neck, sore throat, and body temperature rise to 37.4–37.5 °C, mostly in the evening. Were treated by an otolaryngologist and a dentist without significant effect. In this connection, a biopsy of the ulcerative defect of the left retromolar region was performed, revealing noncaseating granulomatous inflammation. A follow-up examination by a gastroenterologist with colonoscopy and biopsy made it possible to establish Crohn’s disease as the true cause of aphthous stomatitis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>болезнь Крона</kwd><kwd>афтозный стоматит</kwd><kwd>клинический случай</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Crohn’s disease</kwd><kwd>aphthous stomatitis</kwd><kwd>clinical case</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации Российской гастроэнтерологической ассоциации и Ассоциации колопроктологов России по диагностике и лечению болезни Крона [Электронный ресурс]. 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