nogrЭкспериментальная и клиническая гастроэнтерологияExperimental and Clinical Gastroenterology1682-8658«Global Media Technologies»10.31146/1682-8658-ecg-170-10-39-44nogr-1173Research ArticleКЛИНИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯCLINICAL GASTROENTEROLOGYЗаболеваемость, смертность и летальность от хронического гепатита В без и с дельта агентом в Кыргызстане за период 2010–2017 гг.Morbidity, mortality and case fatality rate from chronic hepatitis B with and without a delta agent in Kyrgyzstan for the period 2010–2017НогойбаеваК. А.NogoibaevaK. A.k.nogoibaeva2014@gmail.comТобокаловаС. Т.TobokalovaS. T.КасымбековаК. Т.KasymbekovaK. T.УмароваС. И.UmarovaS. I.Кыргызский государственный медицинский институт переподготовки и повышения квалификации имени С. Б. Даниярова; Кыргызская государственная медицинская академия имени И. К. АхунбаеваРоссияKyrgyz State Medical Institute of Retraining and Advanced Training named after S. B. Daniyarova; Kyrgyz State Medical Academy named after I. K. AkhunbaevRussian FederationКыргызский государственный медицинский институт переподготовки и повышения квалификации имени С. Б. ДанияроваРоссияKyrgyz State Medical Institute of Retraining and Advanced Training named after S. B. DaniyarovaRussian FederationКыргызско-Российский Славянский университет университет имени Б. Н. ЕльцинаРоссияKyrgyz Russian Slavic University named after B. N. YeltsinRussian Federation2019201020191103944Copyright © Ногойбаева К.А., Тобокалова С.Т., Касымбекова К.Т., Умарова С.И., 20192019Ногойбаева К.А., Тобокалова С.Т., Касымбекова К.Т., Умарова С.И.Nogoibaeva K.A., Tobokalova S.T., Kasymbekova K.T., Umarova S.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.nogr.org/jour/article/view/1173Цель исследования

Цель исследования: изучение заболеваемости, смертности и летальности хронического вирусного гепатита В без и с дельта агентом с 2010–2017 гг. в Кыргызстане.

Материалы и методы

Материалы и методы: проанализированы государственные отчетные формы № 12 «Отчет о заболеваемости и профилактической работе (центра семейной медицины, диспансера)» и «С 51 — Распределение умерших по полу, возрастным группам и причинам смерти» с 2010–2017 гг. Данные обработаны программой Microsoft Office Excel.

Результаты

Результаты: В стране с 2010–2017 гг. было выявлено 3292 случая хронического вирусного гепатита В, из них у 1738 больных верифицировано самостоятельное течение (ХВГВ), а у 1554 пациентов — сочетание с дельта агентом (ХВГD), при этом заболеваемость не имела статистически значимой разницы (3,80/0000, 95% ДИ 2,4–4,0 и 3,40/0000, 95% ДИ 2,2–3,4, ХВГВ и ХВГD, соответственно) и был в 20 раз ниже, по сравнению «Носительством HBV» (60,40/0000). Не было статистически значимой разницы между кумулятивной заболеваемостью, летальностью и удельным весом умерших при ХВГВ и ХВГD. Отмечен рост смертности ХВГВ в 4,7 раза (0,090/0000 и 0,410/0000), летальности — в 11,8 раз (1355,00/0000 и 16025,60/0000) на фоне снижения заболеваемости в 2,5 раза (6,40/0000 и 2,50/0000) с 2014 г по 2017 г, соответственно. При ХВГD так же установлен рост смертности в 4,7 раза (0,030/0000 и 0,160/0000), летальности — в 32,3 раза (793,70/0000 и 25641,80/0000) на фоне снижения заболеваемости в 6,9 раза (4.40/0000 и 0.60/0000) с 2014 г по 2017 г, соответственно.

Заключение

Заключение: в Кыргызстане с 2010–2017 гг. выявлена относительно низкая выявляемость ХВГВ и ХВГD по сравнению с «Носительством HBV». Отмечается рост смертности и летальности за последние 4 года с резким подъемом в 2017 г. на фоне тенденции к снижению заболеваемости ХВГВ и ХВГD.

The purpose of the study is to research the morbidity, mortality and case fatality rate y of chronic viral hepatitis B without and with a delta agent from 2010–2017. in Kyrgyzstan.

Materials and methods

Materials and methods: analyzed state reporting forms No. 12 “Report on morbidity and preventive work (family medicine center, dispensary)” and “C51 — Distribution of deaths by sex, age groups and causes of death” from 2010–2017. Data processed by Microsoft Office Excel.

Results

Results: In the country from 2010–2017 3292 cases of chronic viral hepatitis B were detected, 1738 patients of them verified an independent course (СhHBV), and 1,554 patients combined with a delta agent (СhHDV), while the incidence did not have a statistically significant difference (3.80/0000, 95% CI 2.4–4.0 and 3.40/0000, 95% CI 2.2–3.4, СhHBV and СhHDV, respectively) were 20 times lower compared to the HBV Carrier (60 40/0000). There was no statistically significant difference between the cumulative morbidity, mortality, case fatality rate and the proportion of deaths in СhHBV and СhHDV. The death rate СhHBV increased by 4.7 times (0.090/0000 and 0.410/0000), case fatality rate — by 11.8 times (1355.00/0000 and 16025.60/0000) amid a decrease the incidence is 2.5 times (6.40/0000 and 2.50/0000) from 2014 to 2017, respectively. At СhHDV, the mortality rate was also increased by 4.7 times (0.030/0000 and 0.160/0000), case fatality rate — by 32.3 times (793.70/0000 and 25641.80/0000) against the background of a decrease in incidence by 6.9 times (4.40/0000 and 0.60/0000) from 2014 to 2017, respectively.

Conclusion

Conclusion: In Kyrgyzstan from 2010–2017, relatively low detectability of chronic forms of HBV infection with and without delta agent was found, compared with the “HBV carrier”. There has been an increase in mortality and case fatality rate over the past 4 years, with a sharp rise in 2017 against the background of a downward trend in the incidence of СhHBV and СhHDV.

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The authors declare that there are no conflicts of interest present.